Sequential Shh expression in the development of the mouse upper functional incisor
Identifieur interne : 000051 ( France/Analysis ); précédent : 000050; suivant : 000052Sequential Shh expression in the development of the mouse upper functional incisor
Auteurs : Maria Hovorakova [République tchèque] ; Lucie Smrckova [République tchèque] ; Herve Lesot [France] ; Katerina Lochovska [République tchèque] ; Miroslav Peterka [République tchèque] ; Renata Peterkova [République tchèque]Source :
- Journal of Experimental Zoology Part B: Molecular and Developmental Evolution [ 1552-5007 ] ; 2013-11.
Descripteurs français
- Wicri :
- topic : Histologie.
English descriptors
- KwdEn :
- Anlage, Anterior, Anterior domain, Anterior part, Anteriorly, Biol, Body weight, Body weights, Central part, Cheek region, Czech, Czech republic, Dentition, Dimensional reconstruction, Domain, Early development, Early odontogenesis, Early stages, Embryo, Epithelial, Epithelial anlagen, Epithelial bridges, Epithelium, Evol, Experimental medicine, Expression domain, Expression domains, Expression regions, Functional incisor, Functional incisor germ, Histological, Histological sections, Histology, Hovorakova, Hybridization, Hybridized, Hybridized samples, Incisor, Incisor area, Incisor germ, Incisor region, Incisor tooth, Leica, Leica microsystems gmbh, Lesot, Lower incisor, Lower jaws, Maxillary, Maxillary outgrowth, Mcmahon, Molar, More posteriorly, Morphogenesis, Mouse, Mouse embryos, Mouse incisor, Mouse mandible, Mutant mice, Odontogenesis, Peterka, Peterkova, Posteriorly, Pregnant mice, Primordium, Prochazka, Routine histology, Rudimentary, Rudimentary incisor, Rudimentary tooth, Rudimentary tooth primordia, Sequential, Sonic hedgehog, Tamoxifen, Tooth development, Tooth generations, Uorescent, Uorescent microscopy, Upper incisor, Upper incisor area, Upper incisor region, Upper incisors, Upper jaws, Zool.
- Teeft :
- Anlage, Anterior, Anterior domain, Anterior part, Anteriorly, Biol, Body weight, Body weights, Central part, Cheek region, Czech, Czech republic, Dentition, Dimensional reconstruction, Domain, Early development, Early odontogenesis, Early stages, Embryo, Epithelial, Epithelial anlagen, Epithelial bridges, Epithelium, Evol, Experimental medicine, Expression domain, Expression domains, Expression regions, Functional incisor, Functional incisor germ, Histological, Histological sections, Histology, Hovorakova, Hybridization, Hybridized, Hybridized samples, Incisor, Incisor area, Incisor germ, Incisor region, Incisor tooth, Leica, Leica microsystems gmbh, Lesot, Lower incisor, Lower jaws, Maxillary, Maxillary outgrowth, Mcmahon, Molar, More posteriorly, Morphogenesis, Mouse, Mouse embryos, Mouse incisor, Mouse mandible, Mutant mice, Odontogenesis, Peterka, Peterkova, Posteriorly, Pregnant mice, Primordium, Prochazka, Routine histology, Rudimentary, Rudimentary incisor, Rudimentary tooth, Rudimentary tooth primordia, Sequential, Sonic hedgehog, Tamoxifen, Tooth development, Tooth generations, Uorescent, Uorescent microscopy, Upper incisor, Upper incisor area, Upper incisor region, Upper incisors, Upper jaws, Zool.
Abstract
The mouse incisor is a frequently used model in studies of the molecular control of organ development. The appropriate interpretation of data on normogenesis is essential for understanding the data obtained in mutant mice. For this reason, we performed a very detailed investigation of the development of the upper incisor in wild‐type mice from embryonic day (ED) 11.5 till 14.5. A combination of histology, whole mount in situ hybridization, computer‐aided three‐dimensional reconstructions, and fluorescent microscopy, has been used. Several sonic hedgehog (Shh) expression domains have been detected in the upper incisor region during early prenatal development. At ED11.5–13.5, there was a single Shh positive domain present in the anterior part of left or right upper jaw arches, corresponding to the epithelial thickening. More posteriorly, a new Shh expression domain appeared in the incisor bud in the developmentally more advanced ED13.5 embryos. At ED14.5, only this posterior Shh expression in the incisor germ remained detectable. This study brings new insights into the early development of the upper incisor in mice and completes the data on normal mouse incisor development. The temporal–spatial pattern of Shh expression reflects the development of two tooth generations, being detectable in two successive, antero‐posteriorly located areas in the prospective incisor region in the upper jaw. The first, anterior and superficial Shh expression domain reflects the rudimentary tooth development suppressed during evolution. Only the subsequent, posterior and deeper Shh expression region, appearing at ED13.5, correlates with the prospective upper functional incisor in wild‐type mice. J. Exp. Zool. (Mol. Dev. Evol.) 320B: 455–464, 2013. © 2013 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jez.b.22522
Affiliations:
- France, République tchèque
- Alsace (région administrative), Bohême centrale, Grand Est
- Prague, Strasbourg
- Université de Strasbourg
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ISTEX:E03460753271EAF7D4576BF77FC7BDB3CCB0123CLe document en format XML
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development</term><term>Early odontogenesis</term><term>Early stages</term><term>Embryo</term><term>Epithelial</term><term>Epithelial anlagen</term><term>Epithelial bridges</term><term>Epithelium</term><term>Evol</term><term>Experimental medicine</term><term>Expression domain</term><term>Expression domains</term><term>Expression regions</term><term>Functional incisor</term><term>Functional incisor germ</term><term>Histological</term><term>Histological sections</term><term>Histology</term><term>Hovorakova</term><term>Hybridization</term><term>Hybridized</term><term>Hybridized samples</term><term>Incisor</term><term>Incisor area</term><term>Incisor germ</term><term>Incisor region</term><term>Incisor tooth</term><term>Leica</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower incisor</term><term>Lower jaws</term><term>Maxillary</term><term>Maxillary outgrowth</term><term>Mcmahon</term><term>Molar</term><term>More 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xml:lang="en">The mouse incisor is a frequently used model in studies of the molecular control of organ development. The appropriate interpretation of data on normogenesis is essential for understanding the data obtained in mutant mice. For this reason, we performed a very detailed investigation of the development of the upper incisor in wild‐type mice from embryonic day (ED) 11.5 till 14.5. A combination of histology, whole mount in situ hybridization, computer‐aided three‐dimensional reconstructions, and fluorescent microscopy, has been used. Several sonic hedgehog (Shh) expression domains have been detected in the upper incisor region during early prenatal development. At ED11.5–13.5, there was a single Shh positive domain present in the anterior part of left or right upper jaw arches, corresponding to the epithelial thickening. More posteriorly, a new Shh expression domain appeared in the incisor bud in the developmentally more advanced ED13.5 embryos. At ED14.5, only this posterior Shh expression in the incisor germ remained detectable. This study brings new insights into the early development of the upper incisor in mice and completes the data on normal mouse incisor development. The temporal–spatial pattern of Shh expression reflects the development of two tooth generations, being detectable in two successive, antero‐posteriorly located areas in the prospective incisor region in the upper jaw. The first, anterior and superficial Shh expression domain reflects the rudimentary tooth development suppressed during evolution. Only the subsequent, posterior and deeper Shh expression region, appearing at ED13.5, correlates with the prospective upper functional incisor in wild‐type mice. J. Exp. Zool. (Mol. Dev. Evol.) 320B: 455–464, 2013. © 2013 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>France</li><li>République tchèque</li></country><region><li>Alsace (région administrative)</li><li>Bohême centrale</li><li>Grand Est</li></region><settlement><li>Prague</li><li>Strasbourg</li></settlement><orgName><li>Université de Strasbourg</li></orgName></list><tree><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Hovorakova, Maria" sort="Hovorakova, Maria" uniqKey="Hovorakova M" first="Maria" last="Hovorakova">Maria Hovorakova</name></region><name sortKey="Hovorakova, Maria" sort="Hovorakova, Maria" uniqKey="Hovorakova M" first="Maria" last="Hovorakova">Maria Hovorakova</name><name sortKey="Lochovska, Katerina" sort="Lochovska, Katerina" uniqKey="Lochovska K" first="Katerina" last="Lochovska">Katerina Lochovska</name><name sortKey="Lochovska, Katerina" sort="Lochovska, Katerina" uniqKey="Lochovska K" first="Katerina" last="Lochovska">Katerina Lochovska</name><name sortKey="Peterka, Miroslav" sort="Peterka, Miroslav" uniqKey="Peterka M" first="Miroslav" last="Peterka">Miroslav Peterka</name><name sortKey="Peterkova, Renata" sort="Peterkova, Renata" uniqKey="Peterkova R" first="Renata" last="Peterkova">Renata Peterkova</name><name sortKey="Smrckova, Lucie" sort="Smrckova, Lucie" uniqKey="Smrckova L" first="Lucie" last="Smrckova">Lucie Smrckova</name><name sortKey="Smrckova, Lucie" sort="Smrckova, Lucie" uniqKey="Smrckova L" first="Lucie" last="Smrckova">Lucie Smrckova</name></country><country name="France"><region name="Grand Est"><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name></region><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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